In 1902, Charles Richet and Paul Portier, while studying antitoxic immunity to buy robaxin online anemone venom, described the phenomenon of anaphylactic shock. Repeated intravenous administration of poison to previously immunized dogs in an amount significantly less than the lethal dose led to the development of an acute systemic reaction, manifested in vasospasm, collapse and death of animals. The introduction of poison into the skin of immunized animals provoked only a local inflammatory reaction.
At the same time, Maurice Arthus, working with non-toxic forms of the antigen, described one of the forms of a local allergic reaction. The first injection of such an antigen into the skin either did not cause a reaction, or it was very weak. Repeated administration of the same antigen in some cases led to intense infiltration of the injection site with polymorphonuclear leukocytes, hemorrhagic reaction, and vascular necrosis. Another phenomenon associated with allergic reaction has been found in the widespread use of methocarbamol pills anti-diphtheria and anti-tetanus sera for the treatment of related diseases.
The introduction of a significant amount of these sera at the later stages of treatment sometimes led to a systemic reaction, accompanied by fever, rash, urticaria, and in some cases damage to the joints and kidneys. This phenomenon is called serum sickness, as it is associated with the formation of antibodies to the proteins of the administered serum. The ability to develop these allergic reactions in an intact organism can be initiated by the transfer of serum from diseased donors. Moreover, the recipient sensitized in a similar way, with the introduction of a resolving dose of the allergen, will develop the same rapid hypersensitivity response as the serum donor.
These early results clearly indicated that different mechanisms underlie the two forms of robaxin pills. Pain hypersensitivity is an oversensitive reaction of the soft and hard tissues of the body to external stimuli. Another name for the symptom is hyperalgesia. It manifests itself in acute pain syndrome when exposed to minor mechanical, thermal or chemical factors. It occurs due to damage to local pain receptors or nerve endings of the peripheral system. Leads to order methocarbamol pills skin diseases and neurological disorders. To cure the pathology, you should contact a neurologist or dermatologist.
Hyperalgesia is accompanied by such intense sensations as chills, heat, tingling, burning, pain. In this case, the external stimulus has a weak effect, but the patient feels an acute pain syndrome. Additionally, there may be an increase in heart rate, respiration and heartbeat, fever, excessive sweating. Most often, the symptom affects the skin and teeth. What causes hypersensitivity?